vicissitude
definition
a change of circumstances or fortune, typically one that is unwelcome or unpleasant
example
The vicissitudes of life often teach us valuable lessons, even when they come in the form of hardship.
synonyms
changefluctuationshift
word origin — From Latin 'vicissitudo', meaning 'a turn' or 'change'; related to 'vicis', meaning 'a change' or 'alternation'.