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refractory

adjective/rɪˈfræktəri/

not responding to treatment or difficult to manage

The patient's refractory pain required multiple rounds of treatment before any relief was achieved.

unmanageableresistantobstinate
word origin — from Latin 'refractorius', from 'refringere' meaning 'to break up or break open'

GRE Vocabulary — Set 192

Set 192 of GRE Vocabulary covers 5 words: refractory, saturnine, sedulous, shrill, sordid. Each entry below includes its definition, an example sentence, and synonyms — practice them with the interactive cards above.

  1. refractory · adjective/rɪˈfræktəri/

    not responding to treatment or difficult to manage

    The patient's refractory pain required multiple rounds of treatment before any relief was achieved.

    Synonyms: unmanageable, resistant, obstinate

    Origin: from Latin 'refractorius', from 'refringere' meaning 'to break up or break open'

  2. saturnine · adjective/ˈsætərˌnaɪn/

    gloomy or moody in temperament

    Despite his saturnine demeanor, he surprised everyone with a rare smile during the celebration.

    Synonyms: sullen, morose, gloomy

    Origin: from Latin 'saturninus', meaning 'of Saturn', referring to the planet Saturn, which was associated with gloominess and melancholy in astrology

  3. sedulous · adjective/ˈsɛdʒ.ə.ləs/

    showing dedication and diligence in one’s work or tasks

    Her sedulous efforts in completing the project ahead of schedule did not go unnoticed by her supervisor.

    Synonyms: diligent, assiduous, industrious

    Origin: The word 'sedulous' comes from the Latin 'sedulus', meaning 'busy, diligent'.

  4. shrill · adjective/ʃrɪl/

    having a high-pitched and piercing sound

    The shrill sound of the whistle pierced through the noise of the crowd, grabbing everyone's attention.

    Synonyms: piercing, high-pitched, screeching

    Origin: Middle English 'shril' from Old English 'scrīlle', related to the verb ‘shrill’.

  5. sordid · adjective/ˈsɔrdɪd/

    involving ignoble actions and motives; arousing moral distaste and contempt

    The investigation uncovered a sordid tale of corruption and deceit involving city officials.

    Synonyms: vile, base, despicable

    Origin: From Latin 'sordidus', meaning 'filthy, squalid, or dirty'